At a private East Coast college, two young women meet in art class. Sharon Kisses, quietly ambitious but self-doubting, arrives from rural Kentucky. Mel Vaught, brash, unapologetic, wildly gifted, brings her own brand of hellfire from the backwaters of Florida. Both outsiders, Sharon and Mel become fervent friends, bonding over underground comics and dysfunctional families. A decade later, Sharon and Mel are an award-winning animation duo, and with the release of their first full-length feature, a fearless look at Mel’s childhood, they stand at the cusp of success. But while on tour to promote the film, cracks in their relationship start to form. When unexpected tragedy strikes, long-buried resentments rise to the surface, threatening their partnership and hastening a reckoning no one sees coming.